Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer

Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer
This study is currently recruiting participants.
Verified on November 2011 by National Cancer Institute (NCI)

First Received on May 9, 2009.  
Last Updated on November 18, 2011  
History of Changes
Sponsor: Children’s Oncology Group
Collaborator: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00898079
  Purpose

RATIONALE: Collecting and storing samples of tumor tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help the study of cancer in the future.

PURPOSE: This study is collecting and storing malignant, borderline malignant neoplasms, and related biological samples from young patients with cancer.

Condition Intervention
Leukemia
Neoplasm of Uncertain Malignant Potential
Unspecified Childhood Solid Tumor, Protocol Specific
Other: cytology specimen collection procedure

Study Type: Observational
Official Title: A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:

  • Repository of malignant, borderline malignant neoplasms, and related biological specimens [ Designated as safety issue: No ]

Study Start Date: March 2003

Detailed Description:

OBJECTIVES:

  • Collect malignant, borderline malignant neoplasms, and related biological specimens from Children’s Oncology Group institutions for cases in which there is no disease-specific biologic protocol.
  • Provide a repository for long-term storage of malignant, borderline malignant neoplasms, and related biological specimens from these patients.
  • Make specimens available to qualified researchers to understand the biology of cancer in these patients.

OUTLINE: Tumor tissue samples, blood, and bone marrow aspirates are collected and stored for future analysis.

PROJECTED ACCRUAL: Not specified.

  Eligibility

Ages Eligible for Study:   up to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Meets any of the following criteria:

    • Diagnosed with primary neoplasm
    • Developed a second malignant neoplasm
    • Any diagnoses having an ICD-O Morphology Code ending in 1, 2, or 3 as listed in the International Classification of Disease for Oncology, Third Edition
  • Must have biological specimens including solid tumors and leukemias available

    • Solid tumors meeting the following criteria:

      • Snap frozen primary tumor OR OCT embedded primary tumor OR formalin fixed (block or tissue in formalin) primary tumor AND at least 10 unstained paraffin slides for NIH Mandated QC (tumors that have undergone central pathology review are allowed)

        • Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
    • Plueral fluid or cytologic specimens meeting the following criteria:

      • At least 1 mL of fluid and at least 2 unstained cytospin slides (or 2 unstained smears)

        • Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
    • ALL/AML

      • 3-6 mL of bone marrow aspirate and 10 mL of whole blood
  • Not eligible for disease-specific biology or banking protocol

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00898079

 
Show 175 Study Locations

Sponsors and Collaborators
Children’s Oncology Group
Investigators
Study Chair: Poul Sorensen, MD, PhD British Columbia Cancer Agency
  More Information

Additional Information:

No publications provided

ClinicalTrials.gov Identifier: NCT00898079    
History of Changes
Obsolete Identifiers: NCT00228735
Other Study ID Numbers: CDR0000271415, COG-ABTR01B1
Study First Received: May 9, 2009
Last Updated: November 18, 2011
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):

unspecified childhood solid tumor, protocol specific
childhood acute lymphoblastic leukemia
childhood acute myeloid leukemia/other myeloid malignancies
secondary acute myeloid leukemia
acute undifferentiated leukemia
mast cell leukemia
childhood chronic myelogenous leukemia
juvenile myelomonocytic leukemia
hairy cell leukemia
prolymphocytic leukemia
T-cell large granular lymphocyte leukemia
atypical chronic myeloid leukemia, BCR-ABL1 negative
chronic lymphocytic leukemia
neoplasm of uncertain malignant potential

Additional relevant MeSH terms:

Neoplasms
Leukemia
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on December 02, 2011

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